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About this gene this gene has 31 transcripts (splice variants), 198 orthologues and is associated with 108 phenotypes. About this transcript this transcript has 23 exons, is annotated with 40 domains and features, is associated with 59482 variant alleles and maps to 1279 oligo probes. For both grch38 and hg19 references, the default canonical transcript for the brca1 gene has changed in ion reporter™ software 5.12 for both refseq and ensembl canonical transcripts.
In fact computing the transcript with the longest coding sequence turns out to be quite easy now A filter describing which results to retrieve from the database. The brca1 gene contains 22 exons spanning about 110 kb of dna
The algorithm determines the cds length of each transcript and disqualifies any transcript whose cds length is 75% or less of the longest cds at the locus.
The ensembl canonical transcript is the one that is, on balance, the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as ncbi and uniprot. These methods allow to calculate the lengths of features (transcripts, genes, cds, 3' or 5' utrs) defined in an ensdb object or database
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