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The power reactor information system (pris), developed and maintained by the iaea for over five decades, is a comprehensive database focusing on nuclear power plants worldwide. It is characterized by profound metabolic acidosis and bradycardia which may ultimately lead to cardiac arrest. Mechanism of pris high doses of propofol (greater than 3mg/kg/h) lead to direct inhibition and uncoupling of mitochondrial electron transport chains, leading to greater reliance on anaerobic metabolism.
Aside from propofol dose, other risk factors for pris include critical illness, use of vasopressors and steroids, starvation or malnutrition, and subclinical mitochondrial disease. Propofol infusion syndrome (pris) is a rare and potentially fatal condition that was first reported in children in 1990 The pris act is the privacy and responsible information sharing act 2024 (wa).
Propofol infusion syndrome (pris) is a rare propofol complication, leading to cardiac failure
It was first described in critically ill children and in adults with traumatic brain injury. General measures to support cardiac and renal function should be initiated promptly in patients with suspected pris. First identified in the 1990s, pris can be fatal if not recognized and treated promptly.
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