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Brazilin is obtained from the wood of paubrasilia echinata, biancaea sappan (sappanwood), caesalpinia violacea, and haematoxylum brasiletto Brazilin (c 16 h 14 o 5) is a compound member of homoisoflavonoids, which is a rare subclass of flavonoids (mottaghipisheh & stuppner, 2021) [1] the sappanwood is found in india, malaysia, indonesia and sri lanka, the latter being a major supplier of the wood to europe during the early middle ages.
Brazilin is a promising natural red dye, extracted from the wood of caesalpinia sappan l In addition, it has a biological impact on various pathologies such as alzheimer's disease, parkinson's disease, fibrillogenesis, and osteoarthritis. Brazilin is a red dye precursor obtained from the heartwood of several species of tropical hardwoods
Brazilin inhibits the cells proliferation, promotes apoptosis, and induces autophagy through the ampk/mtor pathway.
Based on the mentioned evidence, this article review aims to determine the future potential of brazilin as an anticancer agent and its mechanism to conclude whether there is a relationship between the activity of iron chelation from the brazilin compound and cancer pathogenesis. Brazilin is a naturally occurring, homoisoflavonoid, red dye obtained from the wood of paubrasilia echinata, biancaea sappan, caesalpinia violacea, and haematoxylum brasiletto (also known as natural red 24 and ci 75280) Brazilin exhibits notable antioxidant properties, primarily attributed to its phenolic hydroxyl groups, which enable free radical scavenging In dpph assays, brazilin demonstrates potent activity with an ic50 value of approximately 57 μm, outperforming vitamin e in ferric reduction and linoleic acid peroxidation inhibition assays
Brazilin (natural red 24) is a red pigment obtained from the wood of the brazilwood family
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