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In this article, we will review and critically analyze the most important advances in the field of substituted hydroxyapatite coatings. This guidance outlines the specific information required in 510 (k) submissions for orthopedic implants with hydroxyapatite (ha) coatings Once finalized, the document will provide recommendations for orthopedic device manufacturers who are submitting devices with metallic, calcium phosphate, or dual coatings to fda for premarket review.
Hydroxyapatite (ha) coatings provide a biocompatible surface to titanium medical implants that can enhance osteointegration and potentially improve patient outcomes.
The investigation of the hydroxyapatite coating and its growth mechanism establish that a stable and reproducible process window has been identified Precise control is achieved, leading to the successful formation of the desired hydroxyapatite films. The regulatory framework for medical implant coatings, particularly hydroxyapatite coatings for bioimplants, is a critical aspect of ensuring patient safety and product efficacy. When final, this document will supersede 510(k) information needed for hydroxyapatite coated orthopedic implants, dated march 10, 1995 (revised february 20, 1997)
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